ES2052608T3 - 1-((4-morfolinil)alquil)-1h-indoles utiles como analgesicos y su preparacion. - Google Patents
1-((4-morfolinil)alquil)-1h-indoles utiles como analgesicos y su preparacion.Info
- Publication number
- ES2052608T3 ES2052608T3 ES88100694T ES88100694T ES2052608T3 ES 2052608 T3 ES2052608 T3 ES 2052608T3 ES 88100694 T ES88100694 T ES 88100694T ES 88100694 T ES88100694 T ES 88100694T ES 2052608 T3 ES2052608 T3 ES 2052608T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- morfolinil
- analgesics
- preparation
- indoles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000730 antalgic agent Substances 0.000 title abstract 2
- 229940035676 analgesics Drugs 0.000 title 1
- SPEUIVXLLWOEMJ-UHFFFAOYSA-N 1,1-dimethoxyethane Chemical compound COC(C)OC SPEUIVXLLWOEMJ-UHFFFAOYSA-N 0.000 abstract 2
- -1 4-MORPHOLINYL Chemical class 0.000 abstract 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- YSMMOVBWZRIVPM-UHFFFAOYSA-N indol-2-ylidenemethanone Chemical compound C1=CC=CC2=NC(=C=O)C=C21 YSMMOVBWZRIVPM-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/013,313 US4840950A (en) | 1987-02-11 | 1987-02-11 | 4-arylcarbonyl-1-[(4-morpholinyl)-lower-alkyl]-1H-indoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2052608T3 true ES2052608T3 (es) | 1994-07-16 |
Family
ID=21759325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES88100694T Expired - Lifetime ES2052608T3 (es) | 1987-02-11 | 1988-01-19 | 1-((4-morfolinil)alquil)-1h-indoles utiles como analgesicos y su preparacion. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4840950A (en]) |
| EP (1) | EP0278265B1 (en]) |
| JP (1) | JP2561939B2 (en]) |
| KR (1) | KR960007523B1 (en]) |
| AR (1) | AR243184A1 (en]) |
| AT (1) | ATE80386T1 (en]) |
| AU (1) | AU596494B2 (en]) |
| CA (1) | CA1299180C (en]) |
| DE (1) | DE3874361T2 (en]) |
| DK (1) | DK167921B1 (en]) |
| ES (1) | ES2052608T3 (en]) |
| FI (1) | FI88152C (en]) |
| GR (1) | GR3005855T3 (en]) |
| IE (1) | IE63264B1 (en]) |
| IL (1) | IL84922A (en]) |
| MX (1) | MX174421B (en]) |
| NO (1) | NO169713C (en]) |
| NZ (1) | NZ223146A (en]) |
| PH (1) | PH25902A (en]) |
| PT (1) | PT86527B (en]) |
| ZA (1) | ZA879723B (en]) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5081122A (en) * | 1990-03-05 | 1992-01-14 | Sterling Drug Inc. | Antiglaucoma compositions containing 4-arylcarbonyl-1-(4-morpholinyl)-lower-alkyl)-1H-indoles and method of use thereof |
| WO2007136790A2 (en) | 2006-05-18 | 2007-11-29 | Mannkind Corporation | Intracellular kinase inhibitors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3215699A (en) * | 1961-06-27 | 1965-11-02 | Warner Lambert Pharmaceutical | Substituted acetylphenyl hydrazones of 2,3-piperidine diones |
| US3182071A (en) * | 1961-06-27 | 1965-05-04 | Warner Lambert Pharmaceutical | Acylated indole derivatives |
| US3487091A (en) * | 1967-12-18 | 1969-12-30 | American Home Prod | 1-(benzyl- or substituted-benzyl)-3-(2-substituted-ethyl) indoles |
| GB1374414A (en) * | 1972-06-12 | 1974-11-20 | Sterling Drug Inc | 1-acyl-3-amino-alkyl-indoles and their preparation |
| GB1436771A (en) * | 1973-02-16 | 1976-05-26 | Labaz | Indole derivatives and process for preparing the same |
| US4581354A (en) * | 1984-08-06 | 1986-04-08 | Sterling Drug Inc. | 3-arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles, compositions and use |
| PH23498A (en) * | 1984-08-06 | 1989-08-16 | Sterling Drug Inc | 3-carbonyl-1-aminoalkyl-1h-indoles,composition and use thereof |
-
1987
- 1987-02-11 US US07/013,313 patent/US4840950A/en not_active Expired - Lifetime
- 1987-12-22 IL IL84922A patent/IL84922A/xx not_active IP Right Cessation
- 1987-12-29 ZA ZA879723A patent/ZA879723B/xx unknown
-
1988
- 1988-01-04 PH PH36317A patent/PH25902A/en unknown
- 1988-01-08 IE IE4788A patent/IE63264B1/en not_active IP Right Cessation
- 1988-01-11 NZ NZ223146A patent/NZ223146A/en unknown
- 1988-01-12 FI FI880117A patent/FI88152C/fi not_active IP Right Cessation
- 1988-01-12 PT PT86527A patent/PT86527B/pt not_active IP Right Cessation
- 1988-01-13 MX MX010085A patent/MX174421B/es unknown
- 1988-01-19 AU AU10387/88A patent/AU596494B2/en not_active Expired
- 1988-01-19 ES ES88100694T patent/ES2052608T3/es not_active Expired - Lifetime
- 1988-01-19 NO NO880206A patent/NO169713C/no not_active IP Right Cessation
- 1988-01-19 KR KR1019880000361A patent/KR960007523B1/ko not_active Expired - Lifetime
- 1988-01-19 AT AT88100694T patent/ATE80386T1/de not_active IP Right Cessation
- 1988-01-19 DE DE8888100694T patent/DE3874361T2/de not_active Expired - Lifetime
- 1988-01-19 EP EP88100694A patent/EP0278265B1/en not_active Expired - Lifetime
- 1988-01-19 DK DK021588A patent/DK167921B1/da not_active IP Right Cessation
- 1988-01-20 JP JP63010552A patent/JP2561939B2/ja not_active Expired - Lifetime
- 1988-01-20 AR AR88309876A patent/AR243184A1/es active
- 1988-01-26 CA CA000557313A patent/CA1299180C/en not_active Expired - Lifetime
-
1992
- 1992-10-01 GR GR920401725T patent/GR3005855T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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